کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1314585 | 1499349 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The synthesis of α,α-difluoroacetamides via electrophilic fluorination in the mixed-solvent of water and PEG-400
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
• Mild conditions.
• Using minimum amount of industrialized Selectfluor®.
• In mixed-solvent of water and PEG-400 (VH2O:VPEG-400=3:1)(VH2O:VPEG-400=3:1).
• Along without additional phase-transfer catalyst.
• Extensive universality.
Under mild conditions, a series of α,α-difluoro-β-ketoamides were synthesized with Selectfluor® as the F+ source in the presence of K2CO3 in the mixed-solvent of water and PEG-400 (VH2O:VPEG-400=3:1)(VH2O:VPEG-400=3:1), without additional phase-transfer catalyst. By using this approach, most cases examined in this study proceeded in nearly quantitative conversions regardless of the electronic nature of the substituent pattern.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Fluorine Chemistry - Volume 151, July 2013, Pages 45–49
Journal: Journal of Fluorine Chemistry - Volume 151, July 2013, Pages 45–49
نویسندگان
Zhiguo Zhang, Jingjing Bi, Qingfeng Liu, Guisheng Zhang,