A novel catalyst zinc(II) perfluorooctanoate [Zn(PFO)2]-catalyzed three-component one-pot reaction: Synthesis of quinazolinone derivatives in aqueous micellar media

A new type of Lewis acid-surfactant-combined catalyst (LASC), zinc(II) perfluorooctanoate [Zn(PFO)2], was prepared and applied as a favorable surfactivity catalyst in three-component one-pot cyclocondensation reaction of isatoic anhydride with amines and aldehydes to afford the corresponding quinazolinone derivatives in good yields. Reactions occurred under aqueous micellar media in high atom economy. It was found that this catalyst could be easily quantitatively recovered after the reaction completed and could be reused for at least three cycles without any loss of activity. Furthermore, a mechanism to rationalize the reaction was proposed.

Zinc(II) perfluorooctanoate [Zn(PFO)2] is found to catalyze efficiently the three-component one-pot cyclocondensation reaction of isatoic anhydride, amines and aldehydes under aqueous micellar media to afford the corresponding quinazolinone derivatives in good yields.Figure optionsDownload as PowerPoint slide