کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1314670 | 1499350 | 2013 | 7 صفحه PDF | دانلود رایگان |
An efficient, ligand-free palladium-catalyzed method for the cross coupling reaction of pentafluorobenzene with phenols was developed. This reaction proceeds via a highly selective CF bond activation in the 3-position and is compatible with a variety of functional groups, delivering polyfluorinated aryl ethers in moderate to excellent yields.
Palladium-based catalytic systems for cross coupling of pentafluorobenzene and phenols via highly selective CF bond activation in the 3-position have been established. The reactions exhibit good functional group compatibility and afford polyfluorinated aryl ethers in moderate to excellent yields.Figure optionsDownload as PowerPoint slideHighlights
► An efficient Pd-catalyzed method for synthesis of polyfluorinated diaryl ethers has been developed.
► This reaction proceeds with high chemo- and regioselectivity for the CF bond activation.
► A diverse set of important functional groups can be well tolerated in the protocol.
Journal: Journal of Fluorine Chemistry - Volume 150, June 2013, Pages 117–123