Synthesis and skeletal rearrangements of perfluorinated 4-alkyl- and 4-phenyl-tetralin-1-ones under the action of antimony pentafluoride

► Synthesis of perfluorinated 4-methyl-, 4-ethyl- and 4-phenyl-tetralones. ► Skeletal rearrangements of perfluoro-4-R-tetralin-1-ones under the action of SbF5. ► The influence of the substituent group on the reaction route.