کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1314735 | 1499365 | 2012 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis and anti-cancer, anti-metastatic evaluation of some new fluorinated isocoumarins and 3,4-dihydroisocoumarins Synthesis and anti-cancer, anti-metastatic evaluation of some new fluorinated isocoumarins and 3,4-dihydroisocoumarins](/preview/png/1314735.png)
Synthesis of some fluorinated isocoumarins and 3,4-dihydroisocoumarins is reported. Structures of the synthesized compounds were confirmed by spectral and elemental analysis. All the synthesized compounds were evaluated for their antimetastatic activity and anti-cancer activity against breast cell line (MCF-7). Among all the tested compounds 3h [3-(3′,4′-difluorophenyl)isocoumarin] has shown excellent antimetastatic activity, however the growth inhibitory response of the tested compounds [3a–h, 4a–h, 5e–h, 6a–h and 7a, c, d] for MCF-7 human breast carcinoma cell line was moderate at higher concentrations (100–400 μM) and negligible at lower concentrations.
Synthesis of a new series of dihalophenylisocoumarin and 3,4-dihydroisocoumarin derivatives is reported. Synthesized compounds were evaluated for antimetastatic activity and anti-cancer activity against breast cell line (MCF-7).Figure optionsDownload as PowerPoint slideHighlights
► A new series of isocoumarin and 3,4-dihydroisocoumarin derivatives is synthesized.
► These compounds are evaluated for antimetastatic and anti-cancer activities.
► The compound 3h has shown excellent anti-metastatic activity.
► Growth inhibitory response for MCF-7 human breast carcinoma cell line was moderate.
Journal: Journal of Fluorine Chemistry - Volume 135, March 2012, Pages 240–245