کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1314835 975988 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Practical syntheses of 4-fluoroprolines
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Practical syntheses of 4-fluoroprolines
چکیده انگلیسی

4-Fluoroprolines are among the most useful nonnatural amino acids in chemical biology. Here, practical routes are reported for the synthesis of the 2S,4R, 2S,4S, and 2R,4S diastereomers of 4-fluoroproline. Each route starts with (2S,4R)-4-hydroxyproline, which is a prevalent component of collagen and hence readily available, and uses a fluoride salt to install the fluoro group. Hence, the routes provide process-scale access to these useful nonnatural amino acids.

Routes have been developed for the economical, process-scale synthesis of the 2S,4R, 2S,4S, and 2R,4S diastereomers of 4-fluoroproline.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Fluorine Chemistry - Volume 129, Issue 9, September 2008, Pages 781–784
نویسندگان
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