کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1314840 | 975988 | 2008 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Elemental fluorine: Part 22. Fluorination of 3β-acetoxy-5α-androstan-17-one using fluorine and Selectfluor® Elemental fluorine: Part 22. Fluorination of 3β-acetoxy-5α-androstan-17-one using fluorine and Selectfluor®](/preview/png/1314840.png)
Reactions of 3β-acetoxy-5α-androstan-17-one with elemental fluorine and Selectfluor® are reported and give contrasting results. Fluorine gives a mixture of mono-fluorinated steroids in which fluorine atoms are attached to tertiary carbon sites whereas Selectfluor® gives fluoro-steroid systems arising from electrophilic aliphatic substitution of the most sterically accessible secondary saturated positions. The identities of the fluoro-steroid products were determined by NMR analysis and X-ray crystallography.
Fluorination of 3β-acetoxy-5α-androstan-17-one by elemental fluorine gives products arising from fluorination at tertiary CH sites whereas Selectfluor gives products derived from fluorination of CH2 sites.Figure optionsDownload as PowerPoint slide
Journal: Journal of Fluorine Chemistry - Volume 129, Issue 9, September 2008, Pages 811–816