کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1314924 | 975992 | 2007 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Site-specific preparation of 4-substituted-6-fluoro(carboalkoxyl)benzo[b]furans and benzo[b]thiophenes via base-catalyzed cyclization of enyne derivatives Site-specific preparation of 4-substituted-6-fluoro(carboalkoxyl)benzo[b]furans and benzo[b]thiophenes via base-catalyzed cyclization of enyne derivatives](/preview/png/1314924.png)
A site-specific synthesis of 4-substituted-6-fluoro(carboalkoxyl)benzo[b]furans and benzo[b]thiophenes is described. The reactions of heterocyclic aromatic aldehydes with a Wittig reagent, followed by Sonogashira reaction with terminal alkynes, and subsequent base-catalyzed cyclization site-specifically provide 4-substituted-6-fluoro(carboalkoxyl)benzo[b]furans and benzo[b]thiophenes in good yields.
We have demonstrated that 4-substituted-6-fluoro(carboalkoxyl)benzo[b]furans and benzo[b]thiophenes can be prepared site-specifically via base-catalyzed cyclization from the corresponding substituted enynes. Our work continues to explore new applications of this base-catalyzed cyclization in organic chemistry.Figure optionsDownload as PowerPoint slide
Journal: Journal of Fluorine Chemistry - Volume 128, Issue 9, September 2007, Pages 1052–1057