کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1314948 | 975994 | 2009 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis of 2,2,6,6-tetrafluoro-4-phenylmethylmorpholin-3-ones: A simple approach from fluorinated triethylene glycol Synthesis of 2,2,6,6-tetrafluoro-4-phenylmethylmorpholin-3-ones: A simple approach from fluorinated triethylene glycol](/preview/png/1314948.png)
2,2,6,6-Tetrafluoro-4-phenylmethylmorpholin-3-ones are obtained from a new single step, preparative route by reacting triethylene glycol di(trifluoromethanesulfonate), which contains poly –CF2O– groups, with benzylamine. Reaction of trifluoromethylsulfonate and trifluoromethoxy derivatives with benzylamine gave either the nucleophilically-substituted product or the product resulting from the basic hydrolysis of the difluoromethoxy group. Replacement of a fluoroether chain by a fluoroalkane gave rise to fluorinated phenylmethylpiperidine and phenylmethylazepine via the combination of trifluoromethanesulfonic fluoroalkyldiyl esters and benzylamine.
A new synthetic routine was developed for the synthesis of 2,2,6,6-tetrafluoro-4-phenylmethyl-morpholin-3-one by a single step combination of fluorinated triethylene glycol di(trifluoromethanesulfonate) and benzylamine. With a fluoroalkane di(trifluoromethanesulfonate), fluorinated phenylmethylpiperidine and phenylmethylazepine were synthesized by reaction of trifluoromethanesulfonic fluoroalkyldily esters and benzylamine.Figure optionsDownload as PowerPoint slide
Journal: Journal of Fluorine Chemistry - Volume 130, Issue 8, August 2009, Pages 727–732