Rhodium-catalyzed α-fluoroalkylation reaction of ketones using silyl enol ethers

The treatment of silyl enol ethers with fluoroalkyl halides (Rf–X) in the presence of RhCl(PPh3)3 gave α-fluoroalkylated ketones. It seems that a rhodium complex derived from the silyl enol ether and RhCl(PPh3)3 played an important role for the oxidative addition of fluoroalkyl halides and the reductive elimination of the product.

The treatment of silyl enol ethers with fluoroalkyl halides (Rf–X) in the presence of RhCl(PPh3)3 gave α-fluoroalkylated ketones.Figure optionsDownload as PowerPoint slide