A novel and facile synthesis of 2,3-dihydrofuran derivatives containing trifluoromethyl group

A series of CF3-containing 2,3-dihydrofuran derivatives were prepared via the reaction of arsonium bromides 1 with β,β-di(trifluoroacetyl)ethylene derivatives 2 in the presence of K2CO3, usually in a stereoselective manner with moderate yields. The structures of these compounds were confirmed by 1H NMR, 13C NMR, IR, MS and HRMS as well.

The trifluoromethyl containing 2,3-dihydrofuran derivatives 3 were obtained in moderate yield by the reaction of excess arsonium bromides 1 with β,β-di(trifluoroacetyl)ethylene derivatives 2. Figure optionsDownload as PowerPoint slide