کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1315177 | 976008 | 2007 | 8 صفحه PDF | دانلود رایگان |

The arylidienes of fluorinated spiro thiazolidines (5) containing α,β-unsaturated function have been used as component of Micheal addition with equimolar amount of 2-aminopyridine (6a) to give novel fluorinated spiro [indole-3,2′-pyrido[1,2-a]thiazolo[5,4-e]pyrimidines] (7) in a single step under microwaves in presence of montmorillonite KSF as solid support. The new improved synthetic method for fluorinated spiro [indole-3,2′-thiazolo[4,5-d]pyrimidines] (8) has also been developed involving the reaction of (5) with thiourea under monomode microwave reactor. Comparison with conventional synthesis and multimode microwave oven indicated the enhanced yield with faster reactions under monomode microwave reactor. Structure–activity relationships between the chemical structures and the antimycobacterial, antifungal activity of the evaluated compounds are also discussed.
Novel fluorinated spiro [indole-3,2′-pyrido[1,2-a]thiazolo[5,4-e]pyrimidines] (7) and spiro [indole-3,2′-thiazolo[4,5-d]pyrimidines] (8) have been synthesized under microwaves in presence of montmorillonite KSF. Structure–activity relationships between the chemical structures and the antimycobacterial, antifungal activity of the evaluated compounds are also discussed. Figure optionsDownload as PowerPoint slide
Journal: Journal of Fluorine Chemistry - Volume 128, Issue 3, March 2007, Pages 224–231