One-pot synthesis of 4,4-difluoro-3-oxo-2-(triphenylphosphoranylidene)-δ-lactones by Reformatsky reaction

In th presence of zinc and a catalytic amount of cuprous chloride, ethyl 4-bromo-4,4-difluoro-3-oxo-2-(triphenylphosphoranylidene)butanoate 1 reacted with carbonyl compounds to give the gem-difluoromethylenated 2-(triphenylphosphoranylidene)-δ-lactones 4 in moderate to high yields.

In the presence of zinc and a catalytic amount of cuprous chloride, ethyl 4-bromo-4,4-difluoro-3-oxo-2-(triphenylphosphoranylidene)butanoate reacted with carbonyl compounds to give the gem-difluoromethylenated 2-(triphenylphosphoranylidene)-δ-lactones in one-pot in moderate to high yields.Figure optionsDownload as PowerPoint slide