کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1315306 | 976017 | 2006 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A facile synthesis of 4-gem-difluoromethylene β-lactam and its derivatives from BrCF2CF2Br
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A facile synthesis of 4-gem-difluoromethylene β-lactam and its derivatives from BrCF2CF2Br A facile synthesis of 4-gem-difluoromethylene β-lactam and its derivatives from BrCF2CF2Br](/preview/png/1315306.png)
چکیده انگلیسی
4-Bromodifluoromethyl β-lactams 2 are prepared from the commercial available BrCF2CF2Br in overall five-step reaction procedure. Under the radical reaction conditions (Bu3SnH/AIBN), compound 2 reacted with alkenes affording to the corresponding addition product difluoromethylene β-lactams 7. In the absence of alkenes, it can be converted into the corresponding difluoromethyl β-lactam 6 in almost quantitative yield. Furthermore, allylic stannic reagent Bu3SnCH2CHCH2 reacted with 2 under the same reaction conditions gave the allylic addition product 8.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Fluorine Chemistry - Volume 127, Issue 9, September 2006, Pages 1195–1203
Journal: Journal of Fluorine Chemistry - Volume 127, Issue 9, September 2006, Pages 1195–1203
نویسندگان
Hui Wang, Shifa Zhu, Chunhui Xing, Wan Pang, Qinying Deng, Shizheng Zhu,