کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1315406 | 976024 | 2009 | 8 صفحه PDF | دانلود رایگان |

A new nucleophilic difluoromethylenation of aldehydes and ketones using diethyl difluoro(trimethylsilyl)methylphosphonate (1) has been achieved. The reactive carbanion species were generated under mild reaction conditions with a catalytic amount of initiator. This methodology was compatible with non-enolizable and in some cases with enolizable aldehydes and ketones and provided a straightforward access to phosphates of syn and anti 2,2-difluoro-1,3-diols.
Direct nucleophilic introduction of CF2 group to aldehydes and ketones starting from diethyl difluoro(trimethylsilyl)methylphosphonate was achieved. Phosphates of syn and anti 2,2-difluoro-1,3-diols were produced in one reaction sequence and under mild conditions using catalytic amount of fluoride initiator.Figure optionsDownload as PowerPoint slide
Journal: Journal of Fluorine Chemistry - Volume 130, Issue 5, May 2009, Pages 493–500