One-step, synthesis of Hantzsch esters and polyhydroquinoline derivatives in fluoro alcohols

Hantzsch 1,4-dihydropyridine, polyhydroquinoline and 1,8-dioxodecahydroacridines derivatives were synthesized in excellent yields in trifluoroethanol (TFE). The solvent (TFE) can be readily separated from reaction products and recovered in excellent purity for direct reuse.

Hantzsch 1,4-dihydropyridine, polyhydroquinoline and 1,8-dioxodecahydroacridines derivatives were synthesized in excellent yields in trifluoroethanol.Figure optionsDownload as PowerPoint slide