کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1315670 1499369 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Noncovalent fluorous interactions for the synthesis of carbohydrate microarrays
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Noncovalent fluorous interactions for the synthesis of carbohydrate microarrays
چکیده انگلیسی

A surface patterning method based on noncovalent immobilization of fluorous-tagged sugars on fluorous-derivatized glass slides allows the facile fabrication of carbohydrate microarrays. To expand the scope of these arrays, the first syntheses are reported of arabinose, rhamnose, lactose, maltose, and glucosamine tagged with a single C8F17-tail for ease of purification as well as array formation. Screening of these carbohydrate microarrays against lectins from Triticum vulgaris (WGA) and Arachis hypogaea (PNA) demonstrate that the noncovalent fluorous–fluorous interaction is sufficient to retain not only mono- but also disaccharides under the biological assay conditions.

The first syntheses are reported of arabinose, rhamnose, lactose, maltose, and glucosamine tagged with a single C8F17-tail for ease of purification as well as for facile array formation. Screening of these carbohydrate microarrays against two lectins demonstrates that the noncovalent fluorous–fluorous interaction is sufficient to retain both mono- and disaccharides. Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Fluorine Chemistry - Volume 127, Issues 4–5, May 2006, Pages 571–579
نویسندگان
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