Synthesis of novel gem-difluorinatedcyclopropane hybrids: Applications for DNA cleavage agents switched by photo irradiation

A strong DNA cleavage property switched by photo irradiation was found for 9-anthracenecarboxylic acid substituted gem-difluorocyclopropane derivatives; in particular, a clear contrast in the activity was observed between the enantiomers of (S,S)- and (R,R)-3-aminomethyl-2,2-difluorocyclopropylmethyl 9-anthracenecarboxylate.

A unique DNA cleavage property switched by photo irradiation was found for anthracene–cyclopropane hybrids compounds. Figure optionsDownload as PowerPoint slide