کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1315690 976059 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Efficient route to 6-CF3-substituted nicotinic acid derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Efficient route to 6-CF3-substituted nicotinic acid derivatives
چکیده انگلیسی

A novel synthetic sequence for preparation of CF3-pyridines is presented. Reaction of α,β-unsaturated trifluoromethylketones with α-cyanoketones leads to α-hydroxydihydropyranes 1 containing CF3-group. α-Hydroxydihydropyranes can be easily transformed to α-hydroxytetrahydropyridines, 1,4-dihydropyridines and CF3-pyridines. All CF3-pyridine derivatives were obtained in good yields. This route can be applied for preparation of CF3-pyridines containing various substituents with further possible modification on cyano-group.

A novel synthetic sequence for preparation of CF3-pyridines is presented. Reaction of α,β-unsaturated trifluoromethylketones with α-cyanoketones leads to α-hydroxydihydropyranes 1 containing CF3-group. α-Hydroxydihydropyranes can be easily transformed to α-hydroxytetrahydropyridines, 1,4-dihydropyridines and CF3-pyridines. All CF3-pyridine derivatives were obtained in good yields. This route can be applied for preparation of CF3-pyridines containing various substituents with further possible modification on cyano-group. Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Fluorine Chemistry - Volume 127, Issue 7, July 2006, Pages 865–873
نویسندگان
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