New functionalized, differently fluorinated building-blocks via Michael addition to γ-fluoro-α-nitroalkenes

The Michael addition of ketone-derived enamines, metalated methylene active compounds and N-methyl pyrroles to γ-fluoro-α-nitroalkenes provided in moderate to good isolated yields the corresponding β-fluoroalkyl nitro compounds, which represent new interesting, highly functionalized building blocks in organofluorine chemistry.

The reactivity of differently fluorinated nitroalkenes, three of them prepared for the first time, is investigated.Figure optionsDownload as PowerPoint slide