Fluorine in medicinal chemistry: A review of anti-cancer agents

In this review those fluorinated compounds which have found a role as anti-cancer agents are summarized. The emphasis is to highlight the important drugs but also to highlight the latest developments on emerging compounds. This has been done as comprehensively as possible with the objective of informing readers of some of the latest developments in this area.

The occurrence of a fluorine substituent in commercial pharmaceutical compounds has increased from 2% in 1970 to estimates of more than 18% at present. Figure optionsDownload as PowerPoint slide