The chemical transformation of β-bromodifluoromethyl β-enaminoketones: Synthesis of difluoromethylene thioether compounds

A series of 2-bromodifluoromethylquinoline derivatives were synthesized by cyclization of β-bromodifluoromethyl β-enaminoketones catalyzed by polyphosphoric acid. Difluoromethylene thioether or ether derivatives of quinoline and but-2-en-1-one were obtained by the subustitute reaction of CF2Br with thio- and oxygen nucleophiles.

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