On the reactivity of activated alkynes in copper and solvent-free Huisgen’s reaction

Terminal alkynes substituted by a carbonyl-type electron-withdrawing group have been found to undergo Huisgen’s cycloaddition with azides at room temperature in a solvent-free manner; without a need of either heating or catalysis. Metallic salts, other than the copper ones also efficiently catalyzed the reactions. The yields were good and the products isolated mainly as their 1,4-disubstituted isomer.

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