کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1345265 980189 2007 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stereochemistry of internucleotide bond formation by the H-phosphonate method. Part 3: Investigations on a mechanism of asymmetric induction
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Stereochemistry of internucleotide bond formation by the H-phosphonate method. Part 3: Investigations on a mechanism of asymmetric induction
چکیده انگلیسی

The stereochemistry of H-phosphonate diester bond formation (including internucleotide ones) with ribonucleoside H-phosphonates as substrates has been investigated using 31P NMR spectroscopy. It was found that the reactions investigated owe their stereoselectivity to a dynamic kinetic asymmetric transformation. The absolute configurations of the compounds involved in the reaction pathways were tentatively assigned on the basis of their 31P NMR chemical shifts and their correctness was verified for the H-phosphonic–pivalic mixed anhydrides and H-phosphonate aryl esters.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron: Asymmetry - Volume 18, Issue 19, 27 September 2007, Pages 2336–2348
نویسندگان
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