کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1345368 980194 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
HPLC separation and VCD spectroscopy of chiral pyrazoles derived from (5R)-dihydrocarvone
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
HPLC separation and VCD spectroscopy of chiral pyrazoles derived from (5R)-dihydrocarvone
چکیده انگلیسی

(4S,7R)-(−) and (4S,7S)-(+)-4-isopropylidene-7-methyl-4,5,6,7-tetrahydro-2(1)H-indazoles 2a and 2b have been successfully separated by using HPLC over a Chiralpak AS column as the stationary phase, yielding up to 700 mg of each diastereomer. Their absolute configurations were determined by using vibrational circular dichroism (VCD) studies. This latter method proved not only very useful for determination of the conformers’ distribution, but also for analysis of the 1H,2H tautomers.

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4-Isopropylidene-7-methyl-4,5,6,7-tetrahydro-2(1)H-indazoleC11H16N2[α]D23=-29.5 (c 0.49, CH2Cl2)Absolute configuration: (4S, 7R)

4-Isopropylidene-7-methyl-4,5,6,7-tetrahydro-2(1)H-indazoleC11H16N2[α]D23=+15.8 (c 0.51, CH2Cl2)Absolute configuration: (4S, 7S)

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron: Asymmetry - Volume 18, Issue 16, 22 August 2007, Pages 1911–1917
نویسندگان
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