Asymmetric addition of alkynes to imines in water catalyzed with a recyclable Cu(I)–bis(oxazoline) and stearic acid system

Stearic acid and its zinc salt were used as additives in the enantioselective alkyne addition to imines catalyzed by copper(I)–bis(oxazoline) (box) in water. The reactions took place smoothly with good yields and high enantioselectivities (up to 97% ee). Good enantioselectivities were maintained in a catalyst recycle study.

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