The synthesis of chiral 1,2,4-benzothiadiazine derivatives

Novel enantiomerically pure benzothiadiazines were prepared using the commercially available enantiopure (1R,2S,5R)-(−)-menthol and 1,7-dichloro-3-trifluoromethyl-1λ4-benzo[1,2,4]thiadiazine.