کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1345641 | 980214 | 2006 | 5 صفحه PDF | دانلود رایگان |
The synthesis and enantioseparation of chiral 3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide derivatives are reported herein. A HPLC stopped-flow procedure was applied to the determination of rate constants and free energy barriers of enantiomerization of the compounds synthesized in the presence of achiral stationary phase. The individual enantiomers of the studied compounds were isolated in parallel by preparative HPLC on a Chiraspher NT column. Rate constants and free energy barriers of enantiomerization were determined in the mobile phase. The results were used to determine the influence of the chiral stationary phase on the enantiomerization process.
Racemization of individual peak during stopped flow condition.Figure optionsDownload as PowerPoint slide
Journal: Tetrahedron: Asymmetry - Volume 17, Issue 22, 27 November 2006, Pages 3158–3162