کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1345723 1500332 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of organotin derivatives of optically active eleven-membered macrodiolides
ترجمه فارسی عنوان
سنتز مشتقات ارگانوتین از ماکرو دیولیید یازده عضو نوری
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
چکیده انگلیسی

The synthesis and the results obtained in the hydrostannation of eight new TADDOL diacrylates and methacrylates are reported. The addition of triorganotin hydrides, R3SnH, 12–14 (R = nBu, neophyl, Ph, respectively) to diesters 6–11 containing different combinations of substituents at the C-2 carbon of the dioxolane ring, led to macrocyclization products in all cases. The cyclohydrostannation of diacrylate 10 proceeded with complete diastereoselectivity. The cyclohydrostannation of diesters 33 and 34 with hydrides 12 and 14 in all cases only afforded one stannylated macrocycle.

Figure optionsDownload as PowerPoint slide

((4R,5R)-2-Phenyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethylene)diacrylateC41H34O6[α]D25 = −100 (c 0.5, CHCl3)Source of chirality: asymmetric synthesisAbsolute configuration: (4R,5R)

((4R,5R)-2-Phenyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethylene)bis(2-methylacrylate)C43H38O6[α]D25 = −72 (c 0.5, CHCl3)Source of chirality: asymmetric synthesisAbsolute configuration: (4R,5R)

((4R,5R)-2-Methyl-2-phenyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethylene)diacrylateC42H36O6[α]D25 = −19 (c 0.5, CHCl3)Source of chirality: asymmetric synthesisAbsolute configuration: (4R,5R)

((4R,5R)-2-Methyl-2-phenyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethylene)bis(2-methyl-acrylate)C44H40O6[α]D25 = −67 (c 0.5, CHCl3)Source of chirality: asymmetric synthesisAbsolute configuration: (4R,5R)

((4R,5R)-2,2-Diphenyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethylene)diacrylateC47H38O6[α]D25 = −5.4 (c 0.5, CHCl3)Source of chirality: asymmetric synthesisAbsolute configuration: (4R,5R)

((4R,5R)-2,2-Diphenyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethylene)bis(2-methylacrylate)C49H42O6[α]D25 = −4.8 (c 0.5, CHCl3)Source of chirality: asymmetric synthesisAbsolute configuration: (4R,5R)

((4R,5R)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(di(naphthalen-1-yl)-methylene)diacrylateC53H42O6[α]D25 = −170 (c 0.5, CHCl3)Source of chirality: asymmetric synthesisAbsolute configuration: (4R,5R)

((4R,5R)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(di(naphthalen-1-yl)-methylene)bis(2-methylacrylate)C55H46O6[α]D25 = −284 (c 0.5, CHCl3)Source of chirality: asymmetric synthesisAbsolute configuration: (4R,5R)

(3aR,7R,12aR)-2,2,4,4,12,12-Hexaphenyl-7-((tributylstannyl)methyl)hexahydro-6H-[1,3]dioxolo[4,5-c][1,6]dioxacycloundecine-6,10(7H)dioneC59H66O6[α]D25 = −20.8 (c 0.77, CHCl3)Source of chirality: asymmetric synthesisAbsolute configuration: (3aR,7R,12aR)

(3aR,7R,12aR)-2,2,4,4,12,12-Hexaphenyl-7-((trineophylstannyl)methyl)hexahydro-6H-[1,3]dioxolo[4,5-c][1,6]dioxacycloundecine-6,10(7H)dioneC59H66O6[α]D25 = −6.4 (c 0.77, CHCl3)Source of chirality: asymmetric synthesisAbsolute configuration: (3aR,7R,12aR)

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron: Asymmetry - Volume 27, Issues 7–8, 1 May 2016, Pages 352–360
نویسندگان
, , ,