کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1345930 980229 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The first enzymatic resolution of quaternary α′-acetoxy α,β-unsaturated cyclohexenones and cyclopentenones
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
The first enzymatic resolution of quaternary α′-acetoxy α,β-unsaturated cyclohexenones and cyclopentenones
چکیده انگلیسی

The enantioselective resolution of various quaternary α′-acetoxy α,β-unsaturated cyclohexenones and cyclopentenones was performed with the commercially available enzyme CCL in pH = 8.0 phosphate buffer. Various parameters that would affect the enantioselectivities were tested and the best enzymatic resolution conditions were found to afford the enantiomerically enriched quaternary acetoxylated substrates with high ee varying between 36% and 99%.

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(−)-6-Acetoxy-3,6-dimethyl-2-cyclohexen-1-oneC10H14O3Ee = 99%[α]D20=-13.1 (c 1.0, CHCl3)Source of chirality: enzymatic resolution

(−)-6-Acetoxy-3,5,5,6-tetramethyl-2-cyclohexen-1-oneC12H18O3Ee = 62%[α]D20=-1.8 (c 1.0, CHCl3)Source of chirality: enzymatic resolution

(−)-6-Acetoxy-4,4,6-trimethyl-2-cyclohexen-1-oneC11H16O3Ee = 94%[α]D20=-42.2 (c 1.0, CHCl3)Source of chirality: enzymatic resolution

(−)-6-Acetoxy-6-methyl-4,4-diphenyl-2-cyclohexen-1-oneC21H20O3Ee = 73%[α]D20=-29.2 (c 1.0, CHCl3)Source of chirality: enzymatic resolution

(−)-6-Acetoxy-6-ethyl-3-methyl-2-cyclohexen-1-oneC11H16O3Ee = 71%[α]D20=-12.5 (c 1.0, CHCl3)Source of chirality: enzymatic resolution

(+)-6-Acetoxy-6-benzyl-3-methyl-2-cyclohexen-1-oneC16H18O3Ee = 61%[α]D20=+0.4 (c 1.0, CHCl3)Source of chirality: enzymatic resolution

(−)-6-Acetoxy-6-ethyl-3,5,5-trimethyl-2-cyclohexen-1-oneC13H20O3Ee = 45%[α]D20=-3.2 (c 1.0, CHCl3)Source of chirality: enzymatic resolution

(+)-6-Acetoxy-6-benzyl-3,5,5-trimethyl-2-cyclohexen-1-oneC18H22O3Ee = 36%[α]D20=+0.2 (c 1.0, CHCl3)Source of chirality: enzymatic resolution

(−)-5-Acetoxy-3,5-dimethyl-2-cyclopenten-1-oneC9H12O3Ee = 99%[α]D20=-33.6 (c 1.0, CHCl3)Source of chirality: enzymatic resolution

(−)-5-Acetoxy-5-ethyl-3-methyl-2-cyclopenten-1-oneC10H14O3Ee = 53%[α]D20=-8.4 (c 1.0, CHCl3)Source of chirality: enzymatic resolution

(+)-5-Acetoxy-5-benzyl-3-methyl-2-cyclopenten-1-oneC15H16O3Ee = 43%[α]D20=+1.2 (c 1.0, CHCl3)Source of chirality: enzymatic resolution

(−)-5-Acetoxy-2,3,5-trimethyl-2-cyclopenten-1-oneC10H14O3Ee = 90%[α]D20=-23.8 (c 1.0, CHCl3)Source of chirality: enzymatic resolution

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron: Asymmetry - Volume 16, Issue 24, 12 December 2005, Pages 4050–4055
نویسندگان
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