کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1346119 | 980240 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Thioether–phosphinite and diphosphinite ligands derived from d-xylose for the copper-catalyzed asymmetric 1,4-addition to 2-cyclohexenone
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A series of thioether–phosphinite 1–3 and diphosphinite 4 and 5 ligands, derived from inexpensive d-(+)-xylose, were tested for the first time in the Cu-catalyzed asymmetric 1,4-addition to 2-cyclohexenone 6. Good enantioselectivities (up to 72%) and activities [TOF up to >1225 mol (mol h−1)] combined with excellent selectivity in the 1,4 product were obtained. Our results show that activity and selectivity (chemo- and enantioselectivity) depend strongly on the type of functional group at the C-5 position of the carbohydrate backbone, the steric properties of the substituent in the thioether moiety, the catalyst precursor and the alkylating agent.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron: Asymmetry - Volume 16, Issue 12, 20 June 2005, Pages 2161–2165
Journal: Tetrahedron: Asymmetry - Volume 16, Issue 12, 20 June 2005, Pages 2161–2165
نویسندگان
Eugeni Guimet, Montserrat Diéguez, Aurora Ruiz, Carmen Claver,