کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1346209 1500362 2011 31 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Advances in the chemistry of proline and its derivatives: an excellent amino acid with versatile applications in asymmetric synthesis
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Advances in the chemistry of proline and its derivatives: an excellent amino acid with versatile applications in asymmetric synthesis
چکیده انگلیسی

Non-proteinogenic prolines have been acknowledged as an important pool for the synthesis of conformationally rigid bioactive peptides, angiotensin converting enzyme inhibitors and as pharmacological probes. Proline and its derivatives are often used as asymmetric catalysts in organic reactions, such as CBS reductions and proline catalyzed aldol reactions, Mannich reactions, and so on. Furthermore l-proline is an osmoprotectant and is therefore frequently used in many pharmacological as well as biotechnological applications. The wide range of chemical and biological applications associated with l-proline has prompted researchers to develop new methodologies for the synthesis of prolines and substituted prolines and to further explore their chemical and biological applications. The present article is an attempt to discuss all the major advances available till date, describing the use of proline in organic asymmetric synthesis, the synthesis of various bioactive molecules or proline as a constituent part of bioactive molecules.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron: Asymmetry - Volume 22, Issues 20–22, 30 November 2011, Pages 1817–1847
نویسندگان
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