کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1346327 980254 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enantioselective nitroaldol reaction catalyzed by chiral C1-tetrahydro-1,1′-bisisoquinoline-copper(I) complexes
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Enantioselective nitroaldol reaction catalyzed by chiral C1-tetrahydro-1,1′-bisisoquinoline-copper(I) complexes
چکیده انگلیسی
An efficient catalytic system comprising of chiral C1-tetrahydro-1,1′-bisisoquinoline and CuCl in the ratio of 2:1 has been developed for the enantioselective Henry reaction. The catalytic efficiencies of the chiral C1-tetrahydro-1,1′-bisisoquinolines are governed to a great extent by the structural constraints and the type of substituent on the sp3-N. Aromatic and aliphatic aldehydes reacted with nitromethane to give β-nitroalcohols in very high yields (up to 95%) and enantioselectivities (up to 91% ee). The present catalyst system is simple in operation since no special precautions were taken to exclude moisture or air from the reaction flask and no additives were required for activation. Nonlinear effects have also been studied for this reaction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron: Asymmetry - Volume 22, Issue 9, 15 May 2011, Pages 929-935
نویسندگان
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