An enantioselective synthesis of (R)- and (S)-3-amino-7-methyl-3,4-dihydro-1H-[1,8]naphthyridin-2-one

An enantioselective synthesis of (R)- and (S)-3-amino-7-methyl-3,4-dihydro-1H-[1,8]naphthyridin-2-one via an asymmetric reduction and spontaneous cyclisation is reported.

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(S)-3-Amino-7-methyl-3,4-dihydro-1H-[1,8]naphthyridin-2-oneC9H11N3O[α]D25=-82.1 (c 1.0021, water)Source of chirality: Precursor prepared via asymmetric hydrogenationAbsolute configuration: (S)