کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1346525 1500331 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Indolinol-catalyzed asymmetric Michael reaction of aldehydes to nitroalkenes in brine
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Indolinol-catalyzed asymmetric Michael reaction of aldehydes to nitroalkenes in brine
چکیده انگلیسی

(2S,3aS,7aS)-Perhydroindolinol A facilitated the reaction of a wide range of aldehyde and nitroalkene substrates to provide Michael adducts with excellent enantioselectivities (up to 98% ee), excellent yields and high diastereoselectivities (syn/anti up to 99:1). Our results indicated that perhydroindolinols were also highly efficient organocatalysts for asymmetric Michael reactions in brine, while also being environmentally friendly.

Figure optionsDownload as PowerPoint slide

Catalyst BC15H31NOSi[α]D20 = −9.5 (c 0.10, CHCl3)

Catalyst CC25H35NOSi[α]D20 = −8.7 (c 0.25, CHCl3)

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron: Asymmetry - Volume 27, Issues 9–10, 1 June 2016, Pages 420–427
نویسندگان
, , , , , ,