Stereoselective synthesis of GABOB, carnitine and statine phosphonates analogues

γ-Amino acids such as GABA, GABOB, statine and carnitine have attracted considerable attention as biologically active compounds. Over the last few years, significant interest in the stereoselective synthesis of γ-aminophosphonic acids GABOBP, phosphocarnitine, phosphostatine and derivatives has been observed. An overview of synthetic approaches of γ-aminophosphonic acids and derivatives is presented. Data on the practical applications of the γ-aminophosphonic acids are also discussed.

Figure optionsDownload as PowerPoint slide