کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1346676 | 1500366 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Phenol-derived chiral phosphine–phosphite ligands in the rhodium-catalyzed enantioselective hydrogenation of functionalized olefins
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A set of 15 chiral Taddol- and Binol-based phosphine–phosphite ligands were tested in the Rh-catalyzed asymmetric hydrogenation of three olefins, methyl 2-hydroxymethyl-acrylate, 1-phenylvinyl acetate, and α-methyl cinnamic acid. The best enantioselectivities (up to 92% ee) were observed in the hydrogenation of methyl 2-hydroxymethyl-acrylate using Binol-based ligands. As previously observed in other applications of this class of modular chiral ligand in enantioselective catalysis, the stereochemical outcome of the reactions greatly depended on the substituents at the ligand aryl backbone in the ortho-position to the chiral phosphite unit.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron: Asymmetry - Volume 21, Issues 21–22, 25 November 2010, Pages 2671–2674
Journal: Tetrahedron: Asymmetry - Volume 21, Issues 21–22, 25 November 2010, Pages 2671–2674
نویسندگان
Tobias Robert, Zohar Abiri, Albertus J. Sandee, Hans-Günther Schmalz, Joost N.H. Reek,