کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1346942 | 980286 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Enantioselective synthesis of quaternary stereogenic centers through catalytic asymmetric addition of dimethylzinc to α-ketoesters with chiral cis-cyclopropane-based amide alcohol as ligand
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A new amino alcohol with a chiral cyclopropane backbone has been developed and used in the catalytic asymmetric diethylzinc addition to various types of α-ketoesters. This cyclopropane-based chiral amino alcohol shows moderate enantioselectivity in the addition of organozinc to α-ketoesters. For dimethylzinc addition to α-ketoesters, up to 81% ee are obtained, respectively.
Figure optionsDownload as PowerPoint slide
(1R,3S)-N-Benzyl-3-(hydroxymethyl)-2,2-dimethylcyclopropanecarboxamideC14H19NO2Ee = 99%[α]D18=+41.0 (c 1.14, CHCl3)Source of chirality: methyl (+)-cis-chrysanthemateAbsolute configuration: (1R,3S)
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron: Asymmetry - Volume 20, Issue 18, 23 September 2009, Pages 2125–2129
Journal: Tetrahedron: Asymmetry - Volume 20, Issue 18, 23 September 2009, Pages 2125–2129
نویسندگان
Bing Zheng, Shicong Hou, Zhiyuan Li, Hongchao Guo, Jiangchun Zhong, Min Wang,