کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1346989 | 980289 | 2010 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stereoselective lithiation and alkylation and aldol reactions of chiral 5-methyl-3-(o-aryl)-oxazolidinones
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Alkylation and aldol reactions carried out on axially chiral, diastereoenriched oxazolidinedione derivatives were found to be highly stereoselective with respect to substitution at the 5-position of the oxazolidindione ring. Thus, diastereoenriched 5-methyl-3-(o-iodophenyl)-2-thioxo-4-oxazolidinone and 5-methyl-3-(o-aryl)-2,4-oxazolidinediones were prepared and lithiated at C-5 of the oxazolidine ring and the subsequent electrophilic quench with alkyl halides or benzaldehyde yielded products with the same diastereomer ratios as the starting materials.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron: Asymmetry - Volume 21, Issue 20, 28 October 2010, Pages 2455–2464
Journal: Tetrahedron: Asymmetry - Volume 21, Issue 20, 28 October 2010, Pages 2455–2464
نویسندگان
Öznur Demir-Ordu, İlknur Doğan,