Michael reaction of ketones and β-nitrostyrenes catalyzed by camphor-10-sulfonamide-based prolinamide

Novel camphor sulfonamide based organocatalysts were evaluated for their catalytic activity in the Michael reaction of ketones with nitroolefins. Reaction of ketones with β-nitrostyrenes in the presence of 20 mol % organocatalyst 1a and benzoic acid under solvent-free conditions at 0 °C provided the desired Michael adducts with high chemical yields (up to 97%) and excellent stereoselectivities (>99:1).

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