Catalytic enantioselective arylation of aryl aldehydes by chiral aminophenol ligands

The catalytic enantioselective arylation of aryl aldehydes using boronic acids as the source of transferable aryl groups is described; the reaction is found to proceed in good yields and in good to high enantioselectivities (up to 99% ee) in the presence of a chiral aminophenol ligand.

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(R)-2-(1-Amino-2,2-dimethylpropyl)-6-bromo-4-tert-butylphenolC15H24BrNOEe >99%[α]D20=-14.1 (c 1.0, MeOH)Source of chirality: (R)-2-(1-amino-2,2-dimethylpropyl)-4-tert-butylphenolAbsolute configuration: (R)