Effective fungal catalyzed synthesis of P-chiral organophosphorus compounds

An easy and efficient method for the microbial kinetic resolution of a substrate ethyl hydroxy(phenyl)methane(P-phenyl)phosphinate, which contains two stereogenic centers, is reported. To obtain the desired purpose biocatalyst, living fungal cells of Geotrichum candidum were cultivated with or without the supplementation of chemical additives influencing its activity. The biotransformation products were isolated with good yield and in enantiomerically pure forms.

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