کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1347957 | 980332 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Biotransformations of 2,3-epoxy-3-arylpropanenitriles by Debaryomyces hansenii and Mortierella isabellina cells
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Biotransformations of five substituted cis- and trans-oxiranecarbonitriles with Mortierella isabellina DSM 1414, a microbial whole-cell catalyst producing epoxide hydrolases, were investigated. The reactions were stopped when the conversion of the substrates reached 50%. They yielded the appropriate optically active dihydroxycarbonitriles and oxiranecarbonitriles in low enantiomeric purity. Kinetic resolution of rac-syn-2,3-dihydroxy-3-arylpropanenitriles by lipase catalyzed acetylation yielded almost enantiomerically pure (â)-dihydroxynitriles and mixtures of regioisomers of monoacetylated diols. Another microorganism, Debaryomyces hansenii DSM 3428, was used as a source of nitrile hydratases in the kinetic resolution of oxiranecarbonitriles. Only two trans-configured compounds were transformed into the corresponding oxiranecarboxamides.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron: Asymmetry - Volume 19, Issue 12, 30 June 2008, Pages 1455-1460
Journal: Tetrahedron: Asymmetry - Volume 19, Issue 12, 30 June 2008, Pages 1455-1460
نویسندگان
Malgorzata Zagozda, Jan Plenkiewicz,