کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1348185 980343 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Asymmetric reduction of aryl imines using Candida parapsilosis ATCC 7330
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Asymmetric reduction of aryl imines using Candida parapsilosis ATCC 7330
چکیده انگلیسی

A highly enantioselective one pot, novel biocatalytic method for the asymmetric reduction of aryl imines is reported. Treatment of aryl imines with Candida parapsilosis ATCC 7330 in aqueous medium produces the enantiomerically pure (R)-secondary amines in moderate to good yields (55–80%) with excellent enantiomeric excesses (95–>99%).

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(R)-N-(1-Phenylethyl)benzenamineC14H15NEe = 98%[α]D25=-11.4 (c 1.1, CHCl3)Source of chirality: biocatalytic asymmetric reductionAbsolute configuration: (R)

(R)-N-(1-(4-Methoxyphenyl)ethyl)benzenamineC15H17NOEe = 97%[α]D25=-3.97 (c 0.8, CHCl3)Source of chirality: biocatalytic asymmetric reductionAbsolute configuration: (R)

(R)-N-(1-(4-Chlorophenyl)ethyl)benzenamineC14H14ClNEe = 95%[α]D25=-11.9 (c 1.2, CHCl3)Source of chirality: biocatalytic asymmetric reductionAbsolute configuration: (R)

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron: Asymmetry - Volume 19, Issue 1, 30 January 2008, Pages 93–96
نویسندگان
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