Enantioselective hydrogenation of an α-alkoxy substituted ketone with chiral ruthenium (phosphinoferrocenyl)oxazoline complexes

The discovery and optimization of the highly enantioselective asymmetric hydrogenation of an α-alkoxy substituted ketone is described. The use of a ruthenium (phosphinoferrocenyl)oxazoline catalyst and the appropriate choice of a solvent and a base is the key to the success of this transformation.

The discovery and optimization of the highly enantioselective asymmetric hydrogenation of an α-alkoxy substituted ketone is described. The use of a ruthenium (phosphinoferrocenyl)oxazoline catalyst and the appropriate choice of a solvent and a base is the key to the success of this transformation.Figure optionsDownload as PowerPoint slide