Sesquiterpenoid constituents of the liverwort Marsupella aquatica

Nine new amorphane sesquiterpenoids, (+)-7β-hydroxyamorpha-4,11-diene, (−)-9α-hydroxyamorpha-4,7(11)-diene, (−)-3α-hydroxyamorpha-4,7(11)-diene, (−)-3α-acetoxyamorpha-4,7(11)-diene, (−)-amorpha-4,7(11)-dien-3-one, (+)-2,8-epoxyamorpha-4,7(11)-diene, (+)-5,9-epoxyamorpha-3,7(11)-diene, (−)-2α-hydroxyamorpha-4,7(11)-diene and (−)-2β-acetoxyamorpha-4,7(11)-diene, were isolated from the essential oil of the liverwort Marsupella aquatica, collected near Gaschurn/Montafon, Austria. The isolated compounds and their chemical transformations were investigated using enantioselective GC and extensive spectroscopic studies (HRMS, 1H, 13C and 2D NMR). The absolute configuration of most of the isolated compounds were established by conversions to known compounds. In addition, 1H, and 13C NMR data of (−)-myltayl-4-ene are reported for the first time.

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