Ferrocene-based aminophosphine ligands in the Ru(II)-catalysed asymmetric hydrogenation of ketones: assessment of the relative importance of planar versus carbon-centred chirality

Several ferrocene-based aminophosphine ligands have been prepared and shown to be effective in the Ru(II)-catalysed asymmetric hydrogenation of ketones. The enantioselectivity is mainly determined by the carbon-centred chirality of the ligands but the planar chirality is also important such that (RC,SFc)- or (SC,RFc)- are the matched chiralities.

Figure optionsDownload as PowerPoint slide