کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1349086 | 980383 | 2006 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
α-Vinylic amino acids: occurrence, asymmetric synthesis, and biochemical mechanisms
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
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چکیده انگلیسی
This report presents an overview of the family of naturally occurring ‘vinylic’ amino acids, namely those that feature a C–C double bond directly attached to the α-carbon, along the side chain. Strategies that have been brought to bear on the stereocontrolled synthesis of these olefinic amino acids are surveyed. The mechanistic diversity by which such ‘vinylic triggers’ can be actuated in a PLP (pyridoxal phosphate) enzyme active site is then highlighted by discussion of vinylglycine (VG), its substituted congeners, particularly AVG [4E-(2′-aminoethoxy)vinylglycine], and a naturally occurring VG-progenitor, SMM [(S)-methylmethionine].
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron: Asymmetry - Volume 17, Issue 6, 20 March 2006, Pages 869–882
Journal: Tetrahedron: Asymmetry - Volume 17, Issue 6, 20 March 2006, Pages 869–882
نویسندگان
David B. Berkowitz, Bradley D. Charette, Kannan R. Karukurichi, Jill M. McFadden,