کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1349183 | 980387 | 2010 | 6 صفحه PDF | دانلود رایگان |
Concise chemical synthesis of a hexasaccharide repeating unit found in the cell wall lipopolysaccharide of Azospirillum lipoferum Sp59b was achieved in excellent yield. A [3+3] block synthetic strategy has been applied for the construction of the target hexasaccharide. During the synthesis, the orthogonal property of thioglycosides has been successfully exploited. Yields were high in all intermediate steps.
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4-Methoxyphenyl (2,3-di-O-benzyl-4,6-O-benzylidene-α-d-galactopyranosyl)-(1→3)-2,4,6-tri-O-benzyl-β-d-galactopyranosideC55H62O18[α]D25=+5.4 (c 1.0, CHCl3)Source of chirality: d-galactose
4-Methoxyphenyl (2,3,6-tri-O-benzyl-α-d-galactopyranosyl)-(1→3)-2,4,6-tri-O-benzyl-β-d-galactopyranosideC55H64O18[α]D25=+3.6 (c 1.0, CHCl3)Source of chirality: d-galactose
4-Methoxyphenyl (2,3-di-O-acetyl-4,6-O-benzylidene-β-d-glucopyranosyl)-(1→4)-(2,3,6-tri-O-benzyl-α-d-galactopyranosyl)-(1→3)-2,4,6-tri-O-benzyl-β-d-galactopyranosideC72H82O25[α]D25=+2.2 (c 1.0, CHCl3)Source of chirality: d-glucose, d-galactose
Ethyl 2,3,4-tri-O-acetyl-α-l-rhamnopyranosyl-(1→3)-2-O-acetyl-4-O-benzyl-1-thio-α-l-rhamnopyranosideC29H40O12S[α]D25=-8.8 (c 1.0, CHCl3)Source of chirality: l-rhamnose
4-Methoxyphenyl (2,3,4-tri-O-acetyl-α-l-rhamnopyranosyl)-(1→3)-(2-O-acetyl-4-O-benzyl-α-l-rhamnopyranosyl)-(1→2)-3,4-di-O-benzyl-α-l-rhamnopyranosideC54H64O18[α]d25=-6 (c 1.0, CHCl3)Source of chirality: l-rhamnose
4-Methoxyphenyl (2,3,4-tri-O-acetyl-α-l-rhamnopyranosyl)-(1→3)-(2-O-acetyl-4-O-benzyl-α-l-rhamnopyranosyl)-(1→2)-(3,4-di-O-benzyl-α-l-rhamnopyranosyl)-(1→3)-(4,6-O-benzylidene-β-d-glucopyranosyl)-(1→4)-(2,3,6-tri-O-benzyl-α-d-galactopyranosyl)-(1→3)-2,4,6-tri-O-benzyl-β-d-galactopyranosideC131H142O31[α]D25=-10 (c 1.0, CHCl3)Source of chirality: l-rhamnose, d-glucose, d-galactose
4-Methoxyphenyl (2,3,4-tri-O-acetyl-α-l-rhamnopyranosyl)-(1→3)-(2-O-acetyl-4-O-benzyl-α-l-rhamnopyranosyl)-(1→2)-(3,4-di-O-benzyl-α-l-rhamnopyranosyl)-(1→3)-(2-O-acetyl-4,6-O-benzylidene-β-d-mannopyranosyl)-(1→4)-(2,3,6-tri-O-benzyl-α-d-galactopyranosyl)-(1→3)-2,4,6-tri-O-benzyl-β-d-galactopyranosideC133H144O32[α]D25=-7.1 (c 1.0, CHCl3)Source of chirality: l-rhamnose, d-glucose, d-galactose
4-Methoxyphenyl (α-l-rhamnopyranosyl)-(1→3)-(α-l-rhamnopyranosyl)-(1→2)-(α-l-rhamnopyranosyl)-(1→3)-(β-d-mannopyranosyl)-(1→4)-(α-d-galactopyranosyl)-(1→3)-β-d-galactopyranosideC43H68O29[α]D25=+2.7 (c 1.0, CH3OH)Source of chirality: l-rhamnose, d-glucose, d-galactose
Journal: Tetrahedron: Asymmetry - Volume 21, Issue 6, 8 April 2010, Pages 725–730