Chiral bromine–lithium exchange catalyzed by diamines

Different classes of prochiral polyhalide compounds have been tested in a chiral bromine–lithium exchange in the presence of different diamines with enantiomeric excesses of up to 63%.

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2,2′-Dibromo-6,6′-diformylbiphenylC14H8Br2O2Ee = 50%[α]D20=-29.9 (c 0.985, CHCl3)Source of chirality: asymmetric synthesis